Takashi Kojima Selected Research

trifluridine tipiracil drug combination

1/2022	Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.
1/2021	Efficacy and safety of trifluridine/tipiracil plus bevacizumab and trifluridine/tipiracil or regorafenib monotherapy for chemorefractory metastatic colorectal cancer: a retrospective study.
12/2019	Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer.
5/2016	Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors.
1/2016	Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution.

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Takashi Kojima Research Topics

Disease

106	Neoplasms (Cancer) 02/2024 - 01/2002
52	Esophageal Squamous Cell Carcinoma 01/2024 - 01/2011
42	Esophageal Neoplasms (Esophageal Cancer) 04/2024 - 12/2007
30	Dry Eye Syndromes (Dry Eye Syndrome) 01/2023 - 08/2003
22	Stomach Neoplasms (Stomach Cancer) 02/2023 - 12/2003
17	Pancreatic Neoplasms (Pancreatic Cancer) 02/2024 - 08/2010
17	Colorectal Neoplasms (Colorectal Cancer) 02/2024 - 06/2007
17	Inflammation (Inflammations) 10/2023 - 01/2006
17	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2022 - 01/2011
13	Adenocarcinoma 10/2022 - 01/2009
13	Neoplasm Metastasis (Metastasis) 01/2022 - 05/2002
13	Infections 02/2021 - 05/2002
12	Endometrial Neoplasms (Endometrial Cancer) 01/2024 - 11/2013
11	Cataract (Cataracts) 01/2024 - 03/2004
8	Disease Progression 01/2024 - 01/2009
7	Carcinogenesis 01/2023 - 09/2006
7	Allergic Rhinitis 08/2021 - 05/2005
7	Carcinoma (Carcinomatosis) 07/2020 - 04/2003
7	Respiratory Syncytial Virus Infections 01/2016 - 01/2011
6	Keratoconus 01/2024 - 07/2013
6	COVID-19 10/2023 - 01/2021
6	Retinal Detachment (Retinal Detachments) 05/2023 - 01/2017
5	Neutropenia 01/2023 - 12/2019
5	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2023 - 10/2016
5	Astigmatism 01/2023 - 01/2008
5	Myopia 01/2022 - 04/2008
5	Squamous Cell Carcinoma of Head and Neck 01/2021 - 01/2012
5	Proteinuria 01/2020 - 12/2009
4	Adenocarcinoma of Lung 01/2024 - 04/2016
4	Glaucoma 01/2023 - 03/2014
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 01/2006
4	Hypoxia (Hypoxemia) 01/2022 - 07/2011
4	Sepsis (Septicemia) 01/2022 - 10/2010
4	Wounds and Injuries (Trauma) 01/2022 - 01/2009
4	Retinal Perforations 05/2021 - 09/2010
4	Febrile Neutropenia 02/2021 - 08/2011

Drug/Important Bio-Agent (IBA)

29	Proteins (Proteins, Gene)FDA Link 02/2024 - 02/2003
26	Fluorouracil (Carac)FDA LinkGeneric 01/2024 - 08/2002
23	Tight Junction ProteinsIBA 01/2024 - 07/2003
21	Cisplatin (Platino)FDA LinkGeneric 01/2024 - 12/2008
17	Biomarkers (Surrogate Marker)IBA 05/2023 - 12/2011
16	Claudin-4IBA 01/2019 - 12/2004
15	Docetaxel (Taxotere)FDA Link 01/2024 - 11/2010
13	CytokinesIBA 01/2022 - 01/2006
11	NivolumabIBA 02/2024 - 01/2017
11	Claudin-1IBA 11/2016 - 07/2003
10	pembrolizumabIBA 04/2024 - 01/2019
10	Ophthalmic Solutions (Eye Drops)IBA 01/2023 - 02/2005
10	ClaudinsIBA 01/2023 - 08/2006
10	OccludinIBA 01/2020 - 12/2004
9	Immune Checkpoint InhibitorsIBA 02/2024 - 05/2017
9	Messenger RNA (mRNA)IBA 09/2022 - 07/2011
8	Monoclonal AntibodiesIBA 10/2023 - 07/2012
8	Lipoprotein Receptors (Lipoprotein Receptor)IBA 12/2021 - 05/2016
8	MARVEL Domain Containing 2 ProteinIBA 08/2020 - 08/2011
7	Small Interfering RNA (siRNA)IBA 02/2024 - 09/2011
7	Histone Deacetylase InhibitorsIBA 01/2024 - 10/2007
7	HMGB1 Protein (HMG1)IBA 12/2023 - 01/2020
7	Irinotecan (Camptosar)FDA LinkGeneric 12/2020 - 12/2008
6	regorafenibIBA 02/2024 - 12/2016
6	AntigensIBA 01/2023 - 05/2005
6	PlatinumIBA 10/2022 - 01/2017
6	Fluorescein (Funduscein)FDA LinkGeneric 01/2021 - 11/2018
6	diquafosolIBA 07/2020 - 07/2013
6	Clostridium enterotoxinIBA 11/2013 - 09/2011
5	Histone Deacetylases (Histone Deacetylase)IBA 01/2024 - 01/2017
5	Paclitaxel (Taxol)FDA LinkGeneric 01/2024 - 01/2009
5	Epidermal Growth Factor (EGF)IBA 01/2024 - 08/2003
5	Glucose (Dextrose)FDA LinkGeneric 04/2023 - 02/2016
5	CreatinineIBA 01/2023 - 11/2016
5	LigandsIBA 01/2023 - 02/2007
5	InterferonsIBA 09/2022 - 01/2006
5	trifluridine tipiracil drug combinationIBA 01/2022 - 01/2016
5	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2016 - 01/2007
5	Telomerase (Telomerase Reverse Transcriptase)IBA 11/2014 - 01/2011
4	RNA (Ribonucleic Acid)IBA 02/2024 - 01/2022
4	theasinensin AIBA 01/2024 - 01/2021
4	Claudin-2IBA 01/2023 - 11/2020
4	Retinaldehyde (Retinal)IBA 03/2022 - 05/2007
4	Indicators and Reagents (Reagents)IBA 11/2021 - 10/2010
4	LipidsIBA 01/2021 - 11/2003
4	Bevacizumab (Avastin)FDA Link 01/2021 - 12/2009
4	SodiumIBA 07/2020 - 04/2018
4	rebamipideIBA 08/2019 - 11/2013

Therapy/Procedure

59	Therapeutics 02/2024 - 05/2007
45	Drug Therapy (Chemotherapy) 04/2024 - 07/2007
27	Chemoradiotherapy 10/2023 - 12/2007
14	Neoadjuvant Therapy 01/2024 - 08/2013
12	Esophagectomy 12/2022 - 10/2012
10	Immunotherapy 02/2024 - 07/2011
10	Radiotherapy 12/2023 - 12/2016
6	Aftercare (After-Treatment) 01/2021 - 10/2007
6	Endoscopes 01/2021 - 10/2012
5	Phakic Intraocular Lenses 01/2022 - 04/2012
5	Lasers (Laser) 07/2020 - 01/2008
4	Intraocular Lenses (Intraocular Lens) 01/2024 - 10/2015
4	Laser In Situ Keratomileusis (LASIK) 04/2022 - 04/2008
4	Lymph Node Excision (Lymph Node Dissection) 01/2022 - 01/2019
4	Induction Chemotherapy 02/2021 - 07/2016
4	Photochemotherapy (Photodynamic Therapy) 01/2020 - 09/2012